کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5645656 1407031 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Contact dermatitis considerations in atopic dermatitis
ترجمه فارسی عنوان
تماس با درماتیت در درماتیت آتوپیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی

Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis and allergic contact dermatitis. Suppressing mechanisms between the Th1-driven allergic contact dermatitis and the Th2-driven atopic dermatitis conditions were thought to reduce the simultaneous expression of both; however, recent evidence indicates that pediatric patients with atopic dermatitis are likely to develop clinically relevant positive patch tests and more likely to react to specific allergens, such as lanolin. We review the potential role of skin barrier defects, such as filaggrin mutations and impaired barrier function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms and create an environment favoring sensitization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Dermatology - Volume 35, Issue 4, July–August 2017, Pages 367-374
نویسندگان
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