Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift

In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift.