کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5648922 | 1407110 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Exposure to constant light mimics a certain human lifestyle, such as shift workers or constant lighting conditions at home.
- Exposure to constant light impairs circadian rhythms, leading to the disturbance of neonatal tolerance induction.
- If we try to protect circadian rhythms from environmental perturbation, we may be able to improve the natural course of immunological diseases.
BackgroundAn intrinsic daily physiological rhythm called circadian rhythm has been indicated to affect the immune system and its related diseases. Immune tolerance development is closely associated with the onset of immunological disorders. However, the effect of circadian rhythm in the mechanisms of immune tolerance development has not yet been fully understood.ObjectiveThe purpose of this study was to investigate the effects of circadian rhythm disruption on the development of immune tolerance by the perturbation of light environment, using a mouse model of neonatally induced cutaneous tolerance.MethodsMice were kept under constant light (LL) or light-dark (LD) conditions, and hapten was applied at 2Â days after birth. Six weeks later, hapten was reapplied to abdominal skin, followed by hapten application to ear skin 5Â days later.ResultsThe ear-swelling responses and cell infiltration into inflamed skin significantly increased in LL mice compared with those in LD mice. Interestingly, the percentage and the number of Foxp3+-regulatory T cells notably decreased in inflamed skin and draining lymph nodes of LL mice compared with that in LD mice. Loss-of-function mutation of a key circadian gene, Bmal1, also exacerbated the ear-swelling responses and cell infiltration into inflamed skin in mice.ConclusionThese results suggest that circadian rhythm may be implicated in immune tolerance development in allergic inflammation.
Journal: Journal of Dermatological Science - Volume 86, Issue 1, April 2017, Pages 63-70