کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649063 | 1407114 | 2017 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The skin aging exposome
ترجمه فارسی عنوان
عوارض پیری پوست
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کلمات کلیدی
AHRERKHspIRRMITFJun N-terminal kinaseJNK1/2 - JNK1 / 2Infrared radiation - اشعه مادون قرمزAge - سنextracellular signal regulated kinases - سیگنال خارج سلولی kinases را تنظیم می کندAdvanced glycation end products - محصولات نهایی پیشرفته گلیساسیونHeat shock protein - پروتئین شوک حرارتarylhydrocarbon receptor - گیرنده arylhydrocarbon
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
چکیده انگلیسی
The term “exposome” describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body's response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin has not received major attention and a corresponding definition is lacking. This review was compiled with the collaboration of European scientists, specialized in either environmental medicine or skin biology. A comprehensive review of the existing literature was performed using PubMed. The search was restricted to exposome factors and skin aging. Key review papers and all relevant, epidemiological, in vitro, ex vivo and clinical studies were analyzed to determine the key elements of the exposome influencing skin aging. Here we propose a definition of the skin aging exposome. It is based on a summary of the existing scientific evidence for the role of exposome factors in skin aging. We also identify future research needs which concern knowledge about the interaction of distinct exposomal factors with each other and the resulting net effects on skin aging and suggest some protective measures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 85, Issue 3, March 2017, Pages 152-161
Journal: Journal of Dermatological Science - Volume 85, Issue 3, March 2017, Pages 152-161
نویسندگان
Jean M.D., Anne M.D., Ph.D., Gabrielle Ph.D., Bruno A. Ph.D., Thierry M.D., Ph.D.,