Does elevated serum progesterone on the day of human chorionic gonadotropin administration decrease live birth rates?

The impact of elevated serum progesterone levels on pregnancy and live birth during in vitro fertilization (IVF) remains unclear. Our objective was to investigate whether elevated serum progesterone on the day of human chorionic gonadotropin (HCG) administration is associated with lower pregnancy and live birth rates. This mini review provides a synopsis of the literature in addition to some of our own data. On the whole pregnancy and live birth rates decrease with increasing progesterone on the day of HCG administration even after adjusting for confounders. The findings from the majority of manuscripts investigating this question appear to be in agreement.