کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5656747 | 1407375 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
L'insuline avant Banting et Best
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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چکیده انگلیسی
The discovery of insulin was an enduring adventure and the fruit of many works of morphologists, physiologists, and clinicians. Paul Langerhans described his eponymous islets; Oskar Minkowski and Joseph von Mering produced diabetes in dogs by pancreatectomy; Edouard Laguesse suggested that the islets of Langerhans produced secretion which controlled carbohydrate metabolism. These major discoveries validate the pancreatic origin of diabetes and the emerging doctrine of internal secretions with the feeling that diabetes may be cured by organ extracts. Treatment attempts with varying degrees of success were conducted with obstinacy by clinicians from several countries long before the isolation and use of insulin by Banting and Best, in 1921-1922. Successful isolation of insulin, known as Acomatol and “pancrein”, was first carried out before the Canadian researchers, Banting and Best, published their results. A particular credit goes above all to Züelzer and Reuter, and to Paulescu.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine des Maladies Métaboliques - Volume 10, Issue 5, September 2016, Pages 480-486
Journal: Médecine des Maladies Métaboliques - Volume 10, Issue 5, September 2016, Pages 480-486
نویسندگان
J.-L. Schlienger,