Comparaison d'une intensification de l'insulinothérapie par l'ajout progressif de bolus prandiaux d'insuline asparte par rapport au schéma basal-bolus : résultats de l'étude FullSTEP, un essai clinique randomisé de phase IV en titration forcée

After 32 weeks of treatment, STEP was non inferior to FULL in terms of HbA1c change (mean treatment difference: 0.14 [CI 95%: -0.02; 0.30]). Significantly fewer hypoglycemic episodes occurred in the STEP group. In addition, treatment-emergent adverse events did not differ among groups.