کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5658432 | 1407433 | 2017 | 53 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased Expression of Cytotoxic T-LymphocyteâAssociated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure
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کلمات کلیدی
hepatic sinusoidal endothelial cellCLDCTLA4ALFIQRAPAPAcetaminophen - استامینوفن interferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینHSEC - اینهاChronic liver disease - بیماری کبدی مزمنLiver disease - بیماریهای کبدیPlasma exchange - تبادل پلاسماinfection susceptibility - حساسیت به عفونتTreatment - درمانDendritic cell - سلول دندریتیکinterquartile range - محدوده بین محدبImmune regulation - مقررات ایمنیAcute liver failure - نارسایی حاد کبدیhealthy control - کنترل سالم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased Expression of Cytotoxic T-LymphocyteâAssociated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure Increased Expression of Cytotoxic T-LymphocyteâAssociated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure](/preview/png/5658432.png)
چکیده انگلیسی
Peripheral CD4+ T cells from patients with ALF have increased expression of CTLA4 compared to individuals without ALF; these cells have a reduced response to antigen and CD3 stimulation. We found sera of patients with ALF and from mice with liver injury to have high concentrations of soluble B7, which up-regulates CTLA4 expression by T cells and reduces their response to antigen. Plasma exchange reduces levels of B7 in sera from patients with ALF and might be used to restore antimicrobial responses to patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 153, Issue 1, July 2017, Pages 263-276.e8
Journal: Gastroenterology - Volume 153, Issue 1, July 2017, Pages 263-276.e8
نویسندگان
Wafa Khamri, Robin D. Abeles, Tie Zheng Hou, Amy E. Anderson, Ahmed El-Masry, Evangelos Triantafyllou, Christine Bernsmeier, Fin S. Larsen, Arjuna Singanayagam, Nobuaki Kudo, Lucia A. Possamai, Fanny Lebosse, Georg Auzinger, William Bernal,