کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5658728 1407439 2017 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer
چکیده انگلیسی
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 152, Issue 1, January 2017, Pages 36-52
نویسندگان
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