کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5659603 1407466 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model
چکیده انگلیسی

Background and AimsExtensive excision of the esophageal mucosa by endoscopic submucosal dissection (ESD) frequently evokes a luminal stricture. This study aimed to determine the efficacy of a high-density collagen patch for the prevention of esophageal stricture in extensive ESD.MethodsSix pigs underwent circumferential esophageal ESD under general anesthesia. In 3 pigs, artificial ulcers were covered by 2 collagen patches. The other 3 pigs underwent circumferential ESD only.ResultsThe 2 collagen patches were settled onto the ulcer surface using a general endoscope and instruments. The collagen patch-treated group showed significantly better patency rates on both the oral and anal sides of the wound area compared with the control group at day 14. The mucosal re-epithelization ratio was significantly promoted, and the extent of mucosal inflammation and fibrosis was significantly decreased with the collagen patch treatment in the wound area. The frequency of cells positive α-smooth muscle actin was significantly reduced in the collagen patch-treated group compared with the control group.ConclusionsWe have established a high-density collagen device that can reduce the esophageal stricture associated with extensive ESD. This easy-to-handle device would be useful during superficial esophageal cancer treatment by ESD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 85, Issue 5, May 2017, Pages 1076-1085
نویسندگان
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