کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5662225 1407552 2016 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe
چکیده انگلیسی
Bariatric surgery is the most effective treatment for obesity and diabetes. The 2 most commonly performed weight-loss procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy, improve glycemic control in patients with type 2 diabetes independent of weight loss. One of the early hypotheses raised to explain the immediate antidiabetic effect of RYGB was that rapid delivery of nutrients from the stomach pouch into the distal small intestine enhances enteroinsular signaling to promote insulin signaling. Given the tenfold increase in postmeal glucagon-like peptide-1 (GLP-1) response compared to unchanged integrated levels of postprandial glucose-dependent insulinotropic peptide after RYGB, enhanced meal-induced insulin secretion after this procedure was thought to be the result of elevated glucose and GLP-1 levels. In this contribution to the larger point-counterpoint debate about the role of GLP-1 after bariatric surgery, most of the focus will be on RYGB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgery for Obesity and Related Diseases - Volume 12, Issue 6, July 2016, Pages 1230-1235
نویسندگان
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