کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5680291 1596894 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
miR-206 enhances nasopharyngeal carcinoma radiosensitivity by targeting IGF1
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
miR-206 enhances nasopharyngeal carcinoma radiosensitivity by targeting IGF1
چکیده انگلیسی
Radioresistance remains a major problem in nasopharyngeal carcinoma (NPC) treatment. However, the underlying molecular mechanisms of NPC radioresistance remain poorly understood. The present study aimed to investigate the potential role and mechanism of miR-206 in NPC radioresistance. We observed that miR-206 was down-regulated in radioresistant NPC cells. Furthermore, restoration of miR-206 in CNE2-IR cells suppressed enhanced radiosensitivity of NPC cells. In contrast, inhibition of miR-206 in CNE2 cells reduced the radiosensitivity. We also found that miR-206 directly targeted IGF1 and inhibited the PI3K/AKT pathway. Our data demonstrate that miR-206 sensitizes NPC cell to irradiation by targeting IGF1, highlighting the therapeutic potential of miR-206 in NPC radiosensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Kaohsiung Journal of Medical Sciences - Volume 33, Issue 9, September 2017, Pages 427-432
نویسندگان
, , , ,