کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5689055 1409969 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome
چکیده انگلیسی
Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Kidney International - Volume 90, Issue 4, October 2016, Pages 726-729
نویسندگان
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