Quantified Clinical Risk Change as an End Point During Prostate Cancer Active Surveillance

In this study of men with favorable-risk prostate cancer on active surveillance, we evaluated the change in risk status from initial diagnosis to last biopsy using a readily tabulated clinical instrument. Unit change in the Cancer of the Prostate Risk Assessment (CAPRA) score was associated with increasing risk of adverse pathologic findings at delayed prostatectomy. This framework may be useful to stratify men based on the degree of clinical change from baseline over time.