کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5692478 | 1599345 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic assessment and systemic treatments of invasive local relapses of hormone receptor-positive breast cancer
ترجمه فارسی عنوان
ارزیابی پیشآگهی و درمان سیستماتیک عود مجدد تهاجمی از سرطان پستان گیرنده هورمون
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کلمات کلیدی
ریشه های محلی، سرطان سینه مثبت گیرنده هورمون،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
چکیده انگلیسی
The rate of local recurrences, after breast-conserving surgery or mastectomy for hormone receptor-positive (HR+) breast cancer, has dramatically changed in last decades, due to advances in surgical and radiation techniques and a more extensive use of adjuvant systemic treatments. However, the occurrence of local recurrences remains a major predictor for distant metastasis and is responsible for increased cancer-specific death. It has been estimated that 1 in 4 HR+ and HR-ipsilateral breast recurrences leads to widespread metastatic disease, with an annual mortality rate of 10% in the first 5 years. Nevertheless, very few studies have been conducted to evaluate the optimal care of purely HR+Â local relapses of breast cancer, after surgical removal. In this review we have highlighted the available knowledge on prognostic assessment and systemic treatment for women experiencing local relapses of HR+Â breast cancers, underlying unsolved questions and controversial clinical aspects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 35, October 2017, Pages 162-168
Journal: The Breast - Volume 35, October 2017, Pages 162-168
نویسندگان
Anna Zingarello, Chafika Mazouni, Sofia Rivera, Meriem Mokdad-Adi, Barbara Pistilli,