کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5693497 1410169 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
De-escalating and escalating treatment beyond endocrine therapy in patients with luminal breast cancer
ترجمه فارسی عنوان
درمان در حال افزایش و تشدید درمانی بیش از درمان غدد درون ریز در بیماران مبتلا به سرطان پستان لومینال
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Luminal breast cancers demonstrate significant molecular and clinical heterogeneity, despite the commonality of shared expression of the estrogen receptor (ER). To date, no clinical trial has prospectively investigated the optimal chemotherapy regime according to luminal type, highlighting a paucity of data furthermore required to guide treatment decisions. Current methods of predicting advantage from adjuvant chemotherapy lack refinement and can over-estimate the risk of relapse, inevitably leading to a proportion of patients being unnecessarily exposed to chemotherapy. This paper will explore the evidence behind modalities which may add further value to existing known clinicopathological and molecular profiling techniques in predicting clinical benefit from chemotherapy. Adjuvant chemotherapy regime choice in the context of early luminal breast cancer types will be discussed, and areas for further research and debate identified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 34, Supplement 1, August 2017, Pages S13-S18
نویسندگان
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