کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5696682 1410271 2017 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment
ترجمه فارسی عنوان
سندرم فولیکول خالی بازبینی شده: تعریف، بروز، علایم، تشخیص زودهنگام و درمان
کلمات کلیدی
لقاح آزمایشگاهی، بازیابی اووسیت، فولیکول تخمدان، تحریک تخمدان، ماشه تخمک گذاری،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی
In this review, the definition, incidence and possible causes of empty follicle syndrome (EFS), including molecular mechanisms that may underlie the syndrome, are discussed, along with prevention and treatment options. EFS is the complete failure to retrieve oocytes after ovarian stimulation, despite apparently normal follicle development and adequate follicular steroidogenesis. Two variants of EFS have been described: the 'genuine' form (gEFS), which occurs in the presence of adequate circulating HCG levels at the time of oocyte aspiration, and the 'false' form (f-EFS), which is associated with circulating HCG below a critical threshold. Heterogeneous HCG concentration thresholds, however, have been used to define gEFS, and to date no standardization exist. The situation is unclear when GnRH-analogues are used for ovulation trigger, as the threshold circulating LH and progesterone levels used to define EFS as 'genuine' are not established. The cause of fEFS has been clearly identified as an error in HCG administration at the time of ovulation trigger; in contrast, the cause of gEFS is still unclear, although some pathogenetic hypotheses have been proposed. Optimal treatment and prognosis of these patients are still poorly understood. Large, systematic multi-centre studies are needed to increase the understanding of EFS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive BioMedicine Online - Volume 35, Issue 2, August 2017, Pages 132-138
نویسندگان
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