کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5696693 | 1410271 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The incidence of long heterochromatic polymorphism variants in infants conceived through assisted reproductive technologies
ترجمه فارسی عنوان
بروز انواع مختلف پلی مورفیسم هتروکروماتیک در نوزادان مبتلا به فن آوری های باروری کمک می کند
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کلمات کلیدی
فن آوری های تولید مثل، هتروکروماتین، هترومورفیسم، ناباروری، پلی مورفیسم،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Long heterochromatic variants on chromosomes 1, 9, 16 and Y are suspected to be implicated in infertility and early pregnancy loss, but little is known about how these variants are inherited in children conceived by infertile couples through assisted reproductive technologies. In this case-control study, the incidence of these variants was compared between infants conceived using intracytoplasmic sperm injection (ICSI), IVF and natural intercourse by karyotyping lymphocytes from cord blood or peripheral blood. This study included a total of 647 infants, including 189 conceived by ICSI, 177 by IVF, and 281 naturally conceived (NC). Variants were observed in 13.23% of ICSI, 15.82% of IVF and 12.46% of NC infants, showing that the incidence of variants does not appear to be significantly different between infants conceived using assisted reproductive technologies and infants conceived naturally. Because the parents of these infants were not karyotyped, we can only speculate as to whether these variants were directly inherited. This study concludes that infants born from infertile parents using assisted reproductive technologies to achieve pregnancy do not appear to be any more likely than NC infants of fertile parents to possess long heterochromatic variants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive BioMedicine Online - Volume 35, Issue 2, August 2017, Pages 219-224
Journal: Reproductive BioMedicine Online - Volume 35, Issue 2, August 2017, Pages 219-224
نویسندگان
Andrew Wilson, Katherine Watt, Sai Ma,