کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5696944 1410286 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal determinants of renal mass and function in the fetus and neonate
ترجمه فارسی عنوان
عوامل تعیین کننده مادر در توده کلیوی و عملکرد جنین و نوزادان
کلمات کلیدی
تعیین کننده مادر / جنین، توده کلیوی، نوزاد کلیه،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی
The impact of adverse maternal and early gestational issues, ranging from maternal-fetal interactions all the way through to premature birth, are recognized as having influence on the subsequent development of chronic diseases later in life. The development of chronic kidney disease (CKD) as a direct result of early life renal injury or a sequela of diseases such as hypertension or diabetes is a good model example of the potential impact that early life events may have on renal development and lifelong function. The global monetary and human resource cost of CKD is exorbitant. Socio-economic factors, along with other factors (genetic and environmental) may significantly influence the timing and display of phenotypic expression in fetuses and neonates at risk for developing CKD, yet very few of these factors are studied or well understood. In general our focus has been directed at treatment once CKD is established. This strategy has been and remains short-sighted and costly. Earlier understanding of the intrauterine determinants of renal mass development (i.e. environmental “biomes”, poor maternal-fetal health, socio-economic factors impacting early life events, diet, access to value based health care and educational opportunities on disease evolution) may allow us an opportunity for earlier intervention. This article aims to provide some foundation for improved understanding of the maternal determinants of renal mass and function in the fetus and neonate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Fetal and Neonatal Medicine - Volume 22, Issue 2, April 2017, Pages 67-70
نویسندگان
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