کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5715898 1606468 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ContributionMacrocystic ductal adenocarcinoma of prostate: A rare gross appearance of prostate cancer
ترجمه فارسی عنوان
ابتلا به آدنوکارسینوم مداخله مکررکتیک پروستات: ظاهر ناخوشایند سرطان پروستات
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی


- Macroscopically cyst-forming prostatic adenocarcinoma (MPA) is an extremely rare.
- The high incidence of ductal adenocarcinoma is very characterstic of MPA.
- MPA includes three growth patterns: papillary, flat, and necrotic.
- MPA shows frequent extraprostatic growth, but may be good prognosis.

Macroscopic cyst-formation by prostatic adenocarcinoma, herein referred to as macrocystic prostatic adenocarcinoma (MPA), is extremely rare. To date, no studies of prostate cancer performed based on gross cystic appearance have been reported. MPA can include various diseases, one of which is cystadenocarcinoma. Several cases of ductal adenocarcinoma exhibiting a macrocystic appearance have recently been reported; however, the histological and clinicopathological characteristics of MPAs have yet to be characterized and established. Therefore, we aimed to determine the histological and clinicopathological characteristics of MPA, via a multi-institutional investigation. We discovered five patients with MPA out of 1559 treated patients (0.32%); all cases were ductal adenocarcinomas. MPA was found to have three growth patterns: Two cases showed a prevalence of exuberant papillary proliferation with a fibrovascular core in the macroscopic multilocular cysts. Two others predominantly exhibited multilocular cysts lined by flat epithelium with foci of low papillae, and the fifth had a cystic lesion with intracancerous necrosis. Three of the cases showed extraprostatic invasion; however, none of the patients experienced recurrence during the follow-up period. Each predominant growth pattern tended to exhibit unique clinicopathological characteristics with respect to serum prostate specific antigen level and tumor size and location. In conclusion, we demonstrated that MPA is a ductal adenocarcinoma that is composed of intracystic exuberant papillary proliferation and flat proliferation with foci of low papillae, both of which might exhibit different clinicopathololgical appearances.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Diagnostic Pathology - Volume 27, April 2017, Pages 7-13
نویسندگان
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