کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716135 1606644 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original contributionHigh tumor budding count is associated with adverse clinicopathologic features and poor prognosis in breast carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Original contributionHigh tumor budding count is associated with adverse clinicopathologic features and poor prognosis in breast carcinoma
چکیده انگلیسی


- In ER+/HER2− cancer, tumor budding is significantly associated with distant metastasis.
- In TNBC, H-TB is associated with distant metastasis by univariate analysis.
- In TNBC, tumor budding is associated with LVI and worse overall survival.
- Evaluation of H-TB should be added to the prognostic features of breast carcinoma.

SummaryThis study is to address the significance of tumor budding (TB) in breast carcinoma. Totally 244 estrogen receptor-positive (ER+)/HER2-negative (HER2−) and 131 triple-negative breast carcinoma (TNBC) diagnosed from 2004 to 2014 were analyzed. TB (cluster of up to 5 tumor cells at the invasive front) was evaluated using five 200× high-power fields (HPF) at the hotspot. The highest TB (H-TB) in 1 HPF and average TB (A-TB) in 5 HPFs were correlated with lymph node and distant metastasis, lymphovascular invasion (LVI), local recurrence, overall survival (OS), and disease-free survival (DFS). In ER+/HER2− cancer, H-TB and A-TB were significantly associated with distant metastasis. In TNBC, H-TB was associated with distant metastasis by univariate but not multivariate analysis; H-TB and A-TB were associated with LVI and worse OS (all P < .05). TB is associated with poor prognosis in ER+/HER2− and TNBC cancer. Evaluation of H-TB may be sufficient in breast carcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 66, August 2017, Pages 222-229
نویسندگان
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