کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716202 1606646 2017 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression
چکیده انگلیسی
This study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analyzed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted in pheochromocytoma. Low expression or deletion of miR-96 was predominantly noted in younger patients with pheochromocytoma (<50 years, P = .01). Female patients in the study group showed marked deletion of miR-182 (P = .05). Deletion of the cluster was also associated with SDHB protein expression in pheochromocytoma. Moreover, patients with low miR-183 cluster expression had a slightly better survival rate when compared with patients with high expression. To conclude, the findings indicate a role for miR-183 cluster members in the pathogenesis and clinical progression of pheochromocytoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 64, June 2017, Pages 91-97
نویسندگان
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