کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716498 1606671 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Case ReportPerforated gastric metastasis of Merkel cell carcinoma: Case report and review of the literature
ترجمه فارسی عنوان
گزارش مورد: متاستاز معده پارکورز کارسینوم سلول مرکل: گزارش مورد و بررسی ادبیات
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

A 53 year-old Vietnamese male presented with a complaint of a left buttock mass which had grown to 8.0 cm during the past three years. A CT scan revealed the gluteal lesion and a large mass of the stomach. A biopsy of the gluteal skin lesion was diagnosed as a high grade neuroendocrine carcinoma consistent with Merkel cell carcinoma. Tumor cells in the gastric biopsy showed the same morphology and immunophenotype as seen in the skin biopsy, and expressed synaptophysin, chromogranin, CD56, and cytokeratin (CK) 20 with perinuclear dot-like staining. The diagnosis of gastric metastasis of Merkel cell carcinoma was further confirmed by immunohistochemistry for Merkel cell polyomavirus (MCPyV). The patient underwent one cycle of chemotherapy until he presented with a perforation of the gastric lesion. Surgical resection was performed, with subsequent pathologic analysis of the stomach lesion interpreted as metastatic Merkel cell carcinoma. Herein we describe the first case of perforated gastric metastasis of Merkel cell carcinoma. Histopathological diagnosis of perforated gastric metastasis of Merkel cell carcinoma was established by characteristic immunostains for CK20 and MCPyV in addition to the positive stains for neuroendocrine markers (synaptophysin, chromogranin and CD56).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology: Case Reports - Volume 8, June 2017, Pages 20-23
نویسندگان
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