کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5718202 1411244 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
APSA PaperEffects of anticipated neonatal surgical intervention on maternal milk cytokine production
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
APSA PaperEffects of anticipated neonatal surgical intervention on maternal milk cytokine production
چکیده انگلیسی

BackgroundMaternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome.MethodsDiscarded expressed breast milk (EBM) in the first 3 weeks following delivery was analyzed for IL-23 and IL-10 by ELISA. Variables analyzed included: the need for a pediatric surgical procedure, the need for cardiac surgical procedure, no surgical interventions, and survival. All values are expressed as mean ± SEM. Statistical analysis utilized Kruskal and Mann-Whitney test.ResultsEBM from mothers whose infants required any surgical procedure (n = 19) revealed significant elevation in IL-10 but not IL-23 compared to nonsurgical EBM (n = 18). Subdivided by procedure type, there was no difference between those undergoing a cardiac (n = 9) versus pediatric surgical (n = 10) procedure in both IL-10 and IL-23. Mothers whose infants requiring surgical intervention or whose infants did not survive in the first 3 weeks of life had elevation of IL-10.ConclusionResults suggest maternal stress impacts the cytokine profile of breast milk.Level of evidenceLevel III.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 52, Issue 1, January 2017, Pages 45-49
نویسندگان
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