کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5718334 | 1411247 | 2016 | 5 صفحه PDF | دانلود رایگان |
BackgroundAnticholinergics are well established in the management of neurogenic bladders. However, some patients do have sub-optimal response or severe side effects. This study is designed to assess and compare efficacy of gabapentin with oxybutynin in neurogenic bladders after surgery for spina bifida.MethodsPatients were randomized into three groups after urodynamic studies and started on oxybutynin, gabapentin, and combination of both, respectively. Thorough clinical and urodynamic reassessment was done at 6Â months and one year after starting treatment.ResultsForty-four patients (3-19Â years) were studied. Improvement was noted in symptoms as well as urodynamic parameters in all groups. Maximal improvement of symptom score was with combination of drugs at 1Â year. In urodynamic studies, compliance, pressures, and capacity showed improvement, which was significant between the groups at both six months and 1Â year for bladder pressures and volume. Improvement in compliance though marked was not statistically significant. Best response was seen in group receiving both drugs. Gabapentin was better tolerated than oxybutynin.ConclusionGabapentin is a good alternative to oxybutynin for management of neurogenic bladder, both as monotherapy and as an add-on therapy. It has potential application in patients with inadequate response to anticholinergics.Level of evidence: prospective competitive treatment study - level II.
Journal: Journal of Pediatric Surgery - Volume 51, Issue 12, December 2016, Pages 2025-2029