کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5718374 | 1411248 | 2016 | 6 صفحه PDF | دانلود رایگان |
IntroductionColorectal cancer (CRC) diagnosed before age 30 years is a fatal disease whose biology remains poorly understood. To understand its pathogenesis, we compared molecular and clinical data in surgically treated early-age onset and adult onset patients.Materials and MethodsClinical data and tumor tissue were collected retrospectively for 94 patients with early-age onset CRC (age â¤Â 30 years) and compared to 275 adult CRC patients (age â¥Â 50 years). Tumor morphology, microsatellite instability (MSI) and stability (MSS), KRAS and BRAF mutations, and mismatch repair (MMR) expression (MSH2, MLH1, MSH6, PMS2) were assessed.ResultsEarly-age CRC was distinguished from adult CRC by advanced stage presentation (P < 0.001), frequent high grade cancers (P < 0.001), and poor prognosis (P < 0.001). MSI was associated with favorable survival and MMR loss in both groups. Compared to adults, MSI in early-onset CRC was more prevalent (P < 0.01), not tightly linked to MLH1/PMS2 loss, and never associated with BRAFV600E mutations (P < 0.01). MSS/BRAFV600E genotype had poor prognosis and was more prevalent in early-age CRC (9% vs. 3%).DiscussionSpecific genetic subtypes are found at different frequencies in early-age onset and adult onset CRC. Complete absence of the indolent MSI/BRAFV600E genotype and enrichment in the unfavorable MSS/BRAFV600E genotype help explain the poor prognosis of early onset CRC.
Journal: Journal of Pediatric Surgery - Volume 51, Issue 11, November 2016, Pages 1812-1817