کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5718956 | 1607410 | 2017 | 9 صفحه PDF | دانلود رایگان |
ObjectiveTo study neurocognitive functions and behavior in children with a history of fetal growth restriction (FGR) with brain sparing. We hypothesized that children with FGR would have poorer outcomes on these domains.Study designSubjects were 12-year-old children with a history of FGR born to mothers with severe early-onset hypertensive pregnancy disorders (nâ=â96) compared with a normal functioning full term comparison group with a birth weight â¥2500 g (nâ=â32). Outcome measures were neurocognitive outcomes (ie, intelligence quotient, executive function, attention) and behavior.ResultsFor the FGR group, the mean ratio of the pulsatility index for the umbilical artery/middle cerebral artery (UC-ratioâ=âseverity of brain sparing) was 1.42â±â0.69. The mean gestational age was 31-6/7 â±â2-2/7 weeks. The mean birth weight was 1341 â±â454 g, and the mean birth weight ratio 0.68â±â0.12. Neurocognitive outcomes were comparable between groups. Parents of children with FGR reported more social problems (mean T-score 56.6â±â7.7; comparison 52.3â±â4.3, Pâ<â.001, effect sizeâ=â1, 95% CI 0.52-1.46) and attention problems (mean T-score 57.3â±â6.9; comparison 53.6â±â4.2, Pâ=â.004, effect sizeâ=â0.88, 95% CI 0.42-1.33). UC-ratio was not associated with any of the outcomes, but low parental education and lower birth weight ratio were.ConclusionsIn this prospective follow-up study of 12-year-old children with a history of FGR and confirmed brain sparing, neurocognitive functions were comparable with the comparison group, but parent-reported social and attention problem scores were increased.
Journal: The Journal of Pediatrics - Volume 188, September 2017, Pages 103-109.e2