کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5719518 | 1607421 | 2016 | 8 صفحه PDF | دانلود رایگان |
ObjectivesTo investigate the long-term impact of early-term birth (37-38 weeks' gestation) relative to full-term birth (â¥39 weeks' gestation) on neurodevelopmental and psychiatric outcomes in adolescents with single-ventricle congenital heart disease (CHD).Study designThis cross-sectional cohort study analyzed retrospective medical records from full term adolescents with single-ventricle CHD who underwent the Fontan procedure. Participants underwent neurodevelopmental and psychiatric evaluations, as well as structural brain magnetic resonance imaging. Early-term born adolescents were compared with full-term born adolescents using regression models with adjustments for family social status, birth weight, and genetic abnormality status. Medical and demographic risk factors were examined as well.ResultsCompared with the full-term group (nâ=â100), adolescents born early term (nâ=â33) scored significantly worse on daily-life executive functions, as measured by the Behavior Rating Inventory of Executive Function parent-report (mean scores: early term, 62.0â±â10.9; full-term, 55.6â±â12.2; Pâ=â.009) and self-report (Pâ=â.02) composites. Adolescents born early term were more likely than those born full term to have a lifetime attention-deficit/hyperactivity disorder (ADHD) diagnosis (early term, 55%; full term, 26%; Pâ=â.001). The early-term group also displayed greater psychiatric symptom severity, as indicated by the clinician-reported Brief Psychiatric Rating Scale (mean score: early term, 16.1â±â8.6; full-term, 12.5â±â8.2; Pâ=â.007).ConclusionEarly-term birth is associated with greater prevalence of executive dysfunction, ADHD diagnosis, and psychiatric problems in adolescents with single-ventricle CHD. Early-term birth should be included as a potential risk factor in the algorithm for closer developmental surveillance in CHD.
Journal: The Journal of Pediatrics - Volume 179, December 2016, Pages 96-103