کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5721641 1608099 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperNetwork basis of suicidal ideation in depressed adolescents
ترجمه فارسی عنوان
اساس شبکه ایدۀ خودکشی در نوجوانان افسرده
کلمات کلیدی
اتصال عملکردی ذاتی؛ انسجام شبکه؛ افکار خودکشی؛ بلوغ؛ افسردگی؛ سیستم مدیریت اجرایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- The association between neural network coherence and lifetime severity of suicidal ideation was examined.
- Lower coherence in executive control, default mode, and salience network were each associated with higher suicidal ideation.
- When including all three networks in a single model, only executive control network was associated with suicidal ideation.

BackgroundSuicidal ideation rates rise precipitously in adolescence, contributing to risk for attempts. Although researchers are beginning to explore the brain basis of attempts in depressed adolescents, none have focused on the basis of ideation, which has implications for prevention. This study examined the association between intrinsic neural network coherence and the severity of suicidal ideation in depressed adolescents.MethodsForty adolescents diagnosed with Major Depressive Disorder were administered the Columbia-Suicide Severity Rating Scale and underwent resting-state fMRI. We quantified within-network coherence in the executive control (ECN), default mode (DMN), and salience (SN) networks, and in a non-relevant network consisting of noise signal. We associated coherence in each of these networks with the greatest lifetime severity of suicidal ideation experienced, covarying for motion, age of depression onset, and severity of current depressive and anxious symptoms.ResultsLower coherence in the left ECN, anterior DMN, and SN were independently associated with greater lifetime severity of suicidal ideation. When including all three significant networks and covariates in a single model, only the left ECN significantly predicted suicidal ideation.LimitationStudies with a larger sample size are needed to verify our findings.ConclusionsOur finding of hypoconnectivity in multiple networks extends emerging evidence for hypoconnectivity in adolescent suicidality and is consistent with theoretical conceptualizations of suicidal ideation as a complex set of cognitions associated with cognitive control, self-referential thinking, and processing salient information. While multiple networks could be targets for effective early interventions, those targeting ECN functionality (cognitive control) may be particularly beneficial.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 226, 15 January 2018, Pages 92-99
نویسندگان
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