کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5724779 1411505 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticleClinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Original ArticleClinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection
چکیده انگلیسی

BackgroundRelationships between clinical outcomes and novel respiratory pathogens such as Trichosporon are not well understood.MethodsRespiratory cultures from CF patients were screened for novel pathogens Trichosporon and Chryseobacterium as well as other pathogens over 28 months. Relationships between microbiologic and clinical data were assessed using univariate and multivariate methods.ResultsOf 4934 respiratory cultures from 474 CF patients, 37 cultures from 10 patients were Trichosporon positive. Patients with positive Trichosproron cultures had a greater decline in FEV1 over time (− 3.9%/year vs. -1.3%/year, p < 0.05), whereas Chryseobacterium did not influence lung function. These findings were confirmed in multivariate analyses that included age, gender, and other common pathogens as confounders. Treatment of Trichosporon infected patients was associated with improved lung function.ConclusionsTrichosporon can be recovered from a small but clinically meaningful fraction of CF patients. The presence of Trichosporon, but not Chryseobacterium, is associated with greater declines in lung function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 15, Issue 5, September 2016, Pages e45-e49
نویسندگان
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