Rôle de l'hypoxie dans l'aggravation de la fibrose pulmonaire

There is a strong association between OSAH and incident IPF. Chronic intermittent hypoxia (CIH) associated with OSAH can induce oxydative stress and the pro-inflammatory NFκB pathway. CIH exacerbates animal mortality, lung inflammation and fibrosis in vivo in mice treated with bleomycin.