کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735015 | 1612899 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tolerance to rewarding brain electrical stimulation: Differential effects of contingent and non-contingent activation of parabrachial complex and lateral hypothalamus
ترجمه فارسی عنوان
تحمل به پاداش تحریک الکتریکی مغز: اثرات افتراقی مشروط و غیر وابسته به فعال شدن کمپلکس پاراباژیال و هیپوتالاموس جانبی
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کلمات کلیدی
اولویت محل، پاداش تحریک الکتریکی مغزی، تحریک احتمالی و غیر وابسته، فرابنفشی خارجی فرعی جانبی، هیپوتالاموس جانبی، تحمل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Electrical stimulation of the parabrachial complex and related insular cortex induces concurrent conditioned place preference (CPP) in a naloxone-dependent manner. Furthermore, repeated rewarding activation of these regions generates tolerance, i.e., a reduction of the reinforcing effect. This study examined the effects of contingent and non-contingent stimulation in a CPP task. In the former modality, the animals can voluntarily select areas of the maze and thereby determine whether or not they receive stimulation. In the non-contingent procedure, the animals passively receive the administration of the rewarding electrical current while confined in the preferred place. Tolerance to the rewarding stimulation was observed in the non-contingent procedure, in which the external lateral parabrachial subnucleus (LPBe) was stimulated in a behaviorally passive task, but not in the contingent procedure. In contrast, no tolerance was observed in the group receiving rewarding stimulation of the lateral hypothalamus after either contingent or non-contingent brain activation. These findings are discussed in terms of the rewarding effects induced after contingent or non-contingent administration of electrical or chemical rewarding agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 336, 15 January 2018, Pages 15-21
Journal: Behavioural Brain Research - Volume 336, 15 January 2018, Pages 15-21
نویسندگان
MarÃa M. Hurtado, Amadeo Puerto,