کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5735187 1411857 2017 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of nicotine in the neonatal quinpirole rodent model of psychosis: Neural plasticity mechanisms and nicotinic receptor changes
ترجمه فارسی عنوان
اثرات نیکوتین در مدل جوجه کشی نوزاد نوزادان روانپزشکی: مکانیزم های پلاستیکی عصبی و تغییرات گیرنده های نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Results revealed NQ enhanced nicotine sensitization that was blocked by DhβE. MLA blocked the enhanced nicotine sensitization in NQ animals, but did not block nicotine sensitization. NQ enhanced the NAcc BDNF response to nicotine which was blocked by both antagonists. In Experiment 2, NQ enhanced nicotine sensitization and enhanced α4β2, but not α7, nAChR upregulation in the NAcc. These results suggest a relationship between accumbal BDNF and α4β2 nAChRs and their role in the behavioral response to nicotine in the NQ model which has relevance to schizophrenia, a behavioral disorder with high rates of tobacco smoking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 325, Part A, 15 May 2017, Pages 17-24
نویسندگان
, , , , , , , ,