کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735523 | 1411868 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mice subjected to uncontrollable electric shocks show depression-like behaviors irrespective of their state of helplessness
ترجمه فارسی عنوان
موش ها تحت تاثیر شوک های الکتریکی غیر قابل کنترل نشان می دهد رفتارهای افسردگی بدون در نظر گرفتن وضعیت بی نظمی آنها
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کلمات کلیدی
SPTFSTOFTTSTEZMNLHOpen field test - آزمایش میدان بازsucrose preference test - آزمون ترجیحی ساکارزTail suspension test - آزمون تعلیق دمforced swim test - آزمون شناور اجباریActive avoidance - اجتناب فعالDepression - افسردگیlearned helplessness - بی تفاوتی آموختElectric foot shock - شوک برقی الکتریکیelevated zero maze - لجن صفر بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
The unpredictable and inescapable electric shock-induced “learned helplessness” paradigm has long been used to produce an animal model of depression to identify the molecules associated with depressive symptoms or to assess the efficacy of pharmacological treatments for depression. After exposure to unpredictable and inescapable shocks (uncontrollable stress), most of mice showed defect in escape behavior in active avoidance test (learned helplessness, LH), while others did not (non-learned helplessness, NLH). Here, we investigated whether mice with LH or NLH exhibited depressive symptoms, including anhedonia, anxiety, and despair. We found that compared with control naïve mice, both uncontrollable shocks-induced LH and NLH mice showed increased anhedonia- and anxiety- but not despair-like behaviors. Notably, mice subjected to uncontrollable shocks showed similar behaviors, irrespective of whether they also showed LH or NLH. Furthermore, since both LH and NLH mice showed only anhedonia- and anxiety- but not despair-like behaviors, this model may be generally inadequate for classic depression-like behavior assessment. In conclusion, uncontrollable electric shock induces depression-like behavior, irrespective of the state of helplessness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 322, Part A, 30 March 2017, Pages 138-144
Journal: Behavioural Brain Research - Volume 322, Part A, 30 March 2017, Pages 138-144
نویسندگان
Jin Yong Kim, Soo Hyun Yang, Jihyun Kwon, Hyun Woo Lee, Hyun Kim,