کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5736194 1613224 2017 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular mechanisms of peroxynitrite-induced neuronal death
ترجمه فارسی عنوان
مکانیسم های سلولی مرگ و میر ناشی از پره اکینیتریت
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Peroxynitrite (ONOO−) is a strong biological oxidant formed by the diffusion-limited reaction of nitric oxide (NO−) and superoxide anion (O2−). It has long been theorized that peroxynitrite generation could be the cause in a number of pathological conditions ranging from atherosclerosis to inflammatory, autoimmune, heart and neurodegenerative diseases. Its relatively long biological half-life and high reactivity allows peroxynitrite to oxidize a number of different targets in the cell. In physiologically relevant conditions peroxynitrite can directly react with thiols, or the radical products of peroxynitrite decomposition may indirectly oxidize other cellular components such as lipids, proteins and DNA. Downstream, oxidative modifications caused by peroxynitrite trigger cell death by a variety of mechanisms depending on the concentration of the oxidant. Peroxynitrite stimulates necrosis, apoptosis, autophagy, parthanatos and necroptosis. Here we review the mechanisms activated by peroxynitrite to cause neuronal death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 133, July 2017, Pages 4-11
نویسندگان
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