کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736382 | 1613227 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mir-29a expressions in peripheral blood mononuclear cell and cerebrospinal fluid: Diagnostic value in patients with pediatric tuberculous meningitis
ترجمه فارسی عنوان
عبارات میر 29 در سلول تک هسته ای محیطی و مایع مغزی نخاعی: ارزش تشخیصی در بیماران مبتلا به مننژیت سل اطفال
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
To evaluate the value of miR-29a expression in peripheral blood mononuclear cell (PBMC) and cerebrospinal fluid (CSF) in the diagnosis of pediatric tuberculous meningitis (TBM). Our study enrolled 112 children with TBM and 130 healthy children, from which PBMC and CSF were collected. The quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression of miR-29a in PBMC and CSF, and then analyze the diagnostic value. Compared with control group, the miR-29a expressions in PBMC and CSF were increased in TBM children (both PÂ <Â 0.05), and the expressions were associated with following factors: intracranial hypertension, conscious disturbance, focal cerebral symptoms, meningeal irritation, hydrocrania, abnormal electroencephalogram and extra-cerebral tuberculous (all PÂ <Â 0.05). The receiver operating characteristic (ROC) curve showed that the sensitivity, specificity and area under the curve (AUC) of miR-29a in PBMC was 67.20%, 88.50% and 0.852, respectively, and that in CSF was 81.10%, 90.00% and 0.890, respectively, and that in combination of PBMC and CSF was 84.40%, 95.38% and 0.934, respectively. miR-29a expression in PBMC and CSF may provide a reference for the diagnosis of pediatric TBM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 130, April 2017, Pages 231-235
Journal: Brain Research Bulletin - Volume 130, April 2017, Pages 231-235
نویسندگان
Deng Pan, Miao Pan, Yu-Ming Xu,