کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5736469 1613770 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportTryptophan circuit in fatigue: From blood to brain and cognition
ترجمه فارسی عنوان
گزارش تحقیقاتی تریدپتوفان در خستگی: از خون به مغز و شناخت
کلمات کلیدی
مدار شناختی خستگی، پیوند مرکزی محیطی، تعامل گلیال-نورونال، تریپتوفان، شناخت،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Central fatigue is triggered by synergetic effect of peripheral tryptophan and kynurenine.
- The tryptophan-kynurenine pathway activates in glial-neuronal interactions in central fatigue with cognitive dysfunction.
- Fatigue cognitive circuit includes the tryptophan-kynurenine pathway in the central-peripheral linkage.

Brain tryptophan and its neuroactive metabolites play key roles in central fatigue. However, previous brain function analysis targets may have included both glia and neurons together. Here, we clarified the fatigue-cognitive circuit of the central-peripheral linkage, including the role of glial-neuronal interaction in cognition. Using a rat model of central fatigue induced by chronic sleep disorder (CFSD), we isolated presynaptic terminals and oligodendrocytes. Results showed that compared to control group, presynaptic levels of tryptophan, kynurenine, and kynurenic acid, but not serotonin, in the CFSD group were higher in the hypothalamus and hippocampus. Moreover, CFSD group had higher oligodendrocytic levels of tryptophan, and impaired spatial cognitive memory accuracy and increased hyperactivity and impulsivity. These findings suggest that dynamic change in glial-neuronal interactions within the hypothalamus-hippocampal circuit causes central fatigue, and increased tryptophan-kynurenic acid pathway activity in this circuit causes reduced cognitive function. Additionally, CFSD group had 1.5 times higher plasma levels of tryptophan and kynurenine. Furthermore, in rats undergoing intraperitoneal administration of kynurenine (100 mg/kg) versus vehicle, kynurenine-treated rats showed enhanced production of kynurenic acid in the hippocampus, with suppressed recall of retained spatial cognitive memory. The study revealed that uptake of periphery-derived kynurenine and tryptophan into the brain enhances kynurenic acid production in the brain, and the three factors produce amplification effect involved in the role of central-peripheral linkage in central fatigue, triggering cognitive dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1675, 15 November 2017, Pages 116-126
نویسندگان
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