کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5736936 | 1614507 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tuning neural circuits by turning the interneuron knob
ترجمه فارسی عنوان
تنظیم مدارهای عصبی با چرخاندن دکمه اینترنورون
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Interneurons play a critical role in sculpting neuronal circuit activity and their dysfunction can result in neurological and neuropsychiatric disorders. To temporally structure and balance neuronal activity in the adult brain interneurons display a remarkable degree of subclass-specific plasticity, of which the underlying molecular mechanisms have recently begun to be elucidated. Grafting new interneurons to pre-existing neuronal networks allows for amelioration of circuit dysfunction in rodent models of neurological disease and can reopen critical windows for circuit plasticity. The crucial contribution of specific classes of interneurons to circuit homeostasis and plasticity in health and disease underscores their generation as an important objective for emerging strategies of lineage reprogramming in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Neurobiology - Volume 42, February 2017, Pages 144-151
Journal: Current Opinion in Neurobiology - Volume 42, February 2017, Pages 144-151
نویسندگان
Nathalie Dehorter, Nicolás Marichal, Oscar MarÃn, Benedikt Berninger,