Comparison of mechanisms for contrast-invariance of orientation selectivity in simple cells

Thalamocortical synaptic depression could only be used to counteract a small fraction of the offset otherwise the relationship between contrast and response rate was disrupted. Only broadly tuned simple and complex cell inhibition could counteract the remaining offset for all stimulus contrasts but complex cell inhibition reduced the gain of the response. These results suggest unequal contributions of these feedforward mechanisms with thalamic synaptic noise widening tuning widths for low contrasts, synaptic depression counteracting a small component of the offset and synaptic inhibition completely removing the remaining offset to produce contrast-invariant orientation tuning.