کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738987 1615265 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleThe control of sleep and wakefulness by mesolimbic dopamine systems
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Review articleThe control of sleep and wakefulness by mesolimbic dopamine systems
چکیده انگلیسی


- Dopamine neurons in the ventral tegmental area consolidate wakefulness.
- Role of the nucleus accumbens in regulating slow-wave sleep is discussed.
- Neuronal systems that affect the mesolimbic control of sleep and wake are discussed.

The mesolimbic dopamine pathway between the ventral tegmental area (VTA) and the nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings indicate that the VTA and NAc are also involved in sleep/wake regulation - the topic of this review. First, we present an overview of the growing evidence from rodent studies revealing a wake-regulatory role of VTA dopamine neurons. We also discuss brain areas and their neurotransmitters or neuromodulators that may regulate the activity of wake-promoting VTA dopamine neurons. This is followed by a summary of current knowledge of the role of the NAc in regulating slow-wave sleep and a discussion of where and how this control of sleep physiology might be regulated by upstream neurotransmitters and neuromodulators, including dopamine and the classic somnogen adenosine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 118, May 2017, Pages 66-73
نویسندگان
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