کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5739025 1615270 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice
ترجمه فارسی عنوان
اثرات سیتالوپرام بر فعالیت عضلانی بستن فک، در طول خواب و بیداری در موش
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
In this study, we investigated the effects of chronic administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on sleep/wake cycles and masseter (jaw-closing) muscle electromyogram (EMG) activity over a 24-h period. From the dark to the light period, the times of wakefulness decreased, while those of non-rapid eye movement (NREM) and REM sleep increased. Citalopram did not induce major alterations in the temporal changes of sleep-wake distributions, except for leading to a decrease in the time of NREM sleep during the light period and an increase in the durations of REM sleep episodes. Moreover, citalopram did not modify mean masseter EMG activity during any of the vigilance states and did not affect the temporal changes related to the shifts between dark/light periods. However, citalopram increased the time engaged in masseter EMG activation during NREM sleep in the second and the first halves of the dark and light periods, respectively. These results suggest that chronic citalopram treatment does not affect the temporal changes of sleep-wake distributions, but has a limited facilitatory influence that fails to increase the number of epochs of high levels of masseter muscle activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 113, December 2016, Pages 48-55
نویسندگان
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