کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5739045 | 1615262 | 2017 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship between fear extinction and resilience to drug-dependence in rats
ترجمه فارسی عنوان
رابطه بین انقراض ترس و انعطاف پذیری به وابستگی به مواد مخدر در موش صحرایی
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کلمات کلیدی
انعطاف پذیری استرس، ترس انقراض، ترجیح محل مواجه، تفاوت فردی، موش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Some individuals recover quickly from stressful events, while others do not; this suggests that there are individual differences in stress resilience. Previous studies in rats have shown that an animal's ability to extinguish conditioned fear can predict their stress resilience. In the present study, we investigated whether rats who are resilient or vulnerable to fear conditioning would consistently show resilient or vulnerable behaviors in other behavioral tests. Male Wistar-Imamichi rats were subjected to a series of behavioral tests, including open field, conditioned place-preference (CPP), forced swim and auditory fear conditioning. The subjects were assigned to one of two different groups: resilient or vulnerable, based on their level of freezing during fear extinction, and their other behavioral phenotypes were then compared. Rats in the resilient group showed faster extinction in the methamphetamine-induced CPP test than rats in the vulnerable group. The results suggest that resilience to stressful events is associated with drug-dependence and that individuals' abilities to recover from stressful situations and drug-dependence may share a common mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 121, August 2017, Pages 37-42
Journal: Neuroscience Research - Volume 121, August 2017, Pages 37-42
نویسندگان
Masaharu Ueno, Kazuo Yamada, Yukio Ichitani,