کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5759900 1623779 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hill equation and Hatze's muscle activation dynamics complement each other: enhanced pharmacological and physiological interpretability of modelled activity-pCa curves
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Hill equation and Hatze's muscle activation dynamics complement each other: enhanced pharmacological and physiological interpretability of modelled activity-pCa curves
چکیده انگلیسی


- Steady-states of the muscle activation dynamics from Hatze are connected to the famous Hill equation with benefits for physiology, pharmacology and biomechanics.

In pharmacology, particularly receptor theory, the drug dose-effect relation of bio-active substances is frequently described by a sigmoidal function formulated by A.V. Hill. In biomechanics and muscle physiology then again, H. Hatze had elaborated a mathematical model for the stimulation- and length-dependent dynamics of the calcium-induced activation of mammalian skeletal muscle. Here, we prove that muscular activity-pCa curves described by the Hill equation and the equilibrium state predicted by Hatze's activation dynamics are equivalent. Thus, the exponent introduced by Hatze can be directly identified with its counterpart in the Hill equation, by which the former model gains further physiological interpretability. Conversely, the Hill constant can now be interpreted as a function of the fibre length, generally allowing for advanced Hill plots based on model ideas. We derive and examine the complementary relation of both model approaches, highlight the benefits of mutually viewing one approach from the perspective of the other, and address the physiology behind sigmoidal curves.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 431, 27 October 2017, Pages 11-24
نویسندگان
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