کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5760024 | 1623789 | 2017 | 47 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Force-driven growth of intercellular junctions
ترجمه فارسی عنوان
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کلمات کلیدی
مکانیک انتقال، انرژی آزاد گیبس، رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
Mechanical force regulates the formation and growth of cell-cell junctions. Cadherin is a prominent homotypic cell adhesion molecule that plays a crucial role in establishment of intercellular adhesion. It is known that the transmitted force through the cadherin-mediated junctions directly correlates with the growth and enlargement of the junctions. In this paper, we propose a physical model for the structural evolution of cell-cell junctions subjected to pulling tractions, using the Bell-Dembo-Bongard thermodynamic model. Cadherins have multiple adhesive states and may establish slip or catch bonds depending on the Ca2+ concentration. We conducted a comparative study between the force-dependent behavior of clusters of slip and catch bonds. The results show that the clusters of catch bonds feature some hallmarks of cell mechanotransduction in response to the pulling traction. This is a passive thermodynamic response and is entirely controlled by the effect of mechanical work of the pulling force on the free energy landscape of the junction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 421, 21 May 2017, Pages 101-111
Journal: Journal of Theoretical Biology - Volume 421, 21 May 2017, Pages 101-111
نویسندگان
Mohammad Tehrani, Alireza S. Sarvestani,