کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5790349 1109492 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of selection for scrapie resistance on genetic diversity in a rare and locally adapted sheep breed: The case of Sambucana
ترجمه فارسی عنوان
تاثیر انتخاب بر مقاومت اسکروپین بر تنوع ژنتیکی در نژاد گوسفند نابالغ و موضعی سازگار: مورد سمبوکانا
کلمات کلیدی
گوسفند، مقاومت در برابر زلزله، تنوع ژنتیکی، ژن پروتئین پریون، نشانگر مولکولی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
In Italy, since 2005 a breeding plan to increase scrapie resistance has been adopted. The impact of this selection on genetic diversity was assessed on Sambucana, an autochtonous sheep breed reared in southern Piedmont, by analysing the evolution of allele frequencies at different levels: PRNP (prion protein) gene, microsatellite loci on OAR13 (where PRNR maps), and microsatellite loci on other chromosomes, not subjected to selection for scrapie resistance. A total of 147 young rams, 80 born in 2004 and 67 in 2008-2009 were analysed. Evidence of diversity loss was observed for PRNP gene as a consequence of the directional selection. Diversity was affected in the immediate vicinity of PRNP but the effect on more distant loci on the same chromosome was trivial. With regard to neutral markers, lack of heterozygosis with no changeover of allele frequencies was observed suggesting an increase of inbreeding. Mating policies would be sufficient to solve these problems. A selection scheme based on genotyping rams and eliminating carriers of both susceptible and high susceptible alleles is the best way to improve natural resistance to scrapie with low costs and minimal problems in the current conservation programmes targeting rare breeds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Livestock Science - Volume 157, Issue 1, October 2013, Pages 75-80
نویسندگان
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