Ameliorative effect of lignosulfonate on monocrotophos intoxicated lactating goats

This study was carried out to investigate the ameliorative effect of lignosulfonate as a mechanical antidote on nutrient utilization and blood biochemical profile in cross bred (Alpine × Beetal) lactating goats. A total number of 20 cross bred goats were randomly assigned to four treatments with 5 goats in each. The dietary treatments consisted of the basal diet devoid of supplemental calcium lignosulfonate and monocrotophos (MCP) (control) or were supplemented with calcium lignosulfonate (2.5% DM basis), MCP (25 ppm) or both calcium lignosulfonate (2.5% DM basis) and MCP (25 ppm). At 0, 15, 30, 45 and 60 days intervals, blood samples were collected from jugular vein for the biochemical analysis. Goats were raised for 60 days and a metabolic trial for a period of 6 days was conducted after 45 days of experimental feeding to assess the nutrient digestibility, nitrogen balance and MCP residue in milk and urine. In present findings, intoxication with MCP did not affect (P > 0.05) digestibility, DM intake, body weight change, milk yield and nitrogen balance. However, blood acetylcholine esterase and transaminase activity significantly declined (P < 0.05) in MCP fed goats. Kidney function parameters (serum creatinine and urea concentration) were found similar (P > 0.05) in all treatment groups, indicating no adverse effect of treatments on kidney function. This study suggests that the supplementation of lignosulfonate as mechanical antidote in MCP intoxicated goats reduced its absorption and excretion through urine and milk while increasing its faecal excretion that may be beneficial in public point of view.