کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5796592 1555005 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of mesenchymal stem cells and leukocytes from Large White and Göttingen Minipigs: Clues for stem cell-based immunomodulatory therapies
ترجمه فارسی عنوان
مقایسه سلول های بنیادی مزانشیمی و لکوسیت ها از میکروسکوپ های سفید و گاستینگ: نشانه های درمان سلول های بنیادی ایمونوژئالیست
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

The mesenchymal stem cells (MSCs) are one of the most promising cell types for human and veterinary use and their therapeutic effect is associated with their immunomodulatory properties. Farm animal models, such as pigs, have become a valuable tool to evaluate the safety and efficacy of adoptively transferred MSCs in the setting of veterinary medicine. In order to evaluate the immunomodulatory effect of stem cell-based therapies in porcine breeds, a deep analysis and comparison of MSCs and leukocyte subsets are absolutely necessary. Here we provide a detailed analysis of bone-marrow derived MSCs and leukocyte subsets from Large White pigs and Göttingen Minipigs. Significant differences were observed between the two pig breeds in terms of T cell subsets that need to be considered for immune monitoring of stem cell-based therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 179, 15 October 2016, Pages 63-69
نویسندگان
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