کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5808272 1556078 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticancer activity of aerial parts of Aerva lanata Linn Juss ex Schult against Dalton's Ascitic Lymphoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله
Anticancer activity of aerial parts of Aerva lanata Linn Juss ex Schult against Dalton's Ascitic Lymphoma
چکیده انگلیسی

Background and AimTraditional medicine has a long history of serving people all over the world. In recent years, the use of traditional medicine information in cancer research received considerable interest. Aerva lanata Linn Juss has been used in traditional and folklore medicine for the treatment of cancer. The aim of the present study was to evaluate the effect of methanol (known as MEAL) and aqueous extracts (known as AEAL) of the aerial parts of Aerva lanata Linn Juss against intraperitoneally injected Dalton's Ascitic Lymphoma (DAL) cell lines in Swiss albino mice.Materials and methodsDAL cells were injected intraperitoneally (1 × 106 cells/ml/mouse) to the mice. The MEAL and AEAL at a dose of 200 mg/kg body weight were administered orally for 14 consecutive days to the tumor bearing group of animals. Derived parameters, haematological parameters, serum enzyme and lipid parameters were measured and compared to the cancer control group. 5-Flurouracil (20 mg/kg) was used as a standard.ResultsBoth MEAL and AEAL decreased average increase in body weight, reduced the packed cell volume, viable tumor cell count and increased the life span of DAL treated mice and brought back the haematological parameters, serum enzyme and lipid profile near to normal values. All the values were found to be statistically significant with cancer control group at p < 0.01. These observations are suggestive of the protective effect of extracts in Dalton's Ascitic Lymphoma (DAL).ConclusionAll these findings enable to concluded that MEAL and AEAL possess a protective effect against DAL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Integrative Medicine - Volume 3, Issue 3, September 2011, Pages e245-e250
نویسندگان
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