Immune messengers in Neuralgia Inducing Cavitational Osteonecrosis (NICO) in jaw bone and systemic interference

Aim of the studyIn the practice of the author astounding improvements of systemic complaints which accompanied apparently rheumatic, neuralgic and other chronically inflammatory systemic diseases are consistently observed after cleaning pain free, radiographically normal edentulous areas of the jaw. These are marked by fatty-degenerative osteonecrosis of the cancellous bone. Thus far, in dental research there are only few scientifically proven explanations concerning such systemic therapeutic successes.MethodsIn order to clarify systemic interrelations, samples of cancellous bone have been extracted from six subjects. The specimens were then analyzed by bead-based multiplex technology and tested for 27 immune messengers.ResultsAll six specimens concordantly showed highest concentration for IL1-ra (interleukin-1-receptor antagonist) and RANTES. In addition, in all samples FGFbasic and PDGF-bb have been distinctly evidenced. A statistically high concentration on IL1-RA and RANTES is noticeable here. The samples' small distribution and specific concentration on IL1-ra and RANTES, despite the high number of 27 tested mediators, is a striking figure.