کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5809661 1556162 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Terbinafine hydrochloride nanovesicular gel: In vitro characterization, ex vivo permeation and clinical investigation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Terbinafine hydrochloride nanovesicular gel: In vitro characterization, ex vivo permeation and clinical investigation
چکیده انگلیسی

In this work, nanovesicular chitosan gels were prepared for dermal delivery of terbinafine hydrochloride (TBN HCl). Ethosomes and vesicles containing different types of penetration enhancers (PEs) viz. Terpenes (cineole and limonene), labrasol and transcutol were developed. The prepared vesicles were evaluated for physical characteristics as well as skin interaction. The selected vesicles were incorporated into chitosan gel. An in vivo animal study was done on rat induced superficial Candida infection model. Moreover, randomized double blind clinical study was done on patients to compare the effect of the selected nanovesicular gel against the market product. Results showed the formation of nearly spherical, mostly deformable vesicular systems with size range of 95.5-530 nm, zeta potential range of − 0.1 to 15 mV and entrapment efficiency range of 20-96.7%. Penetration enhancer vesicles (PEVs) prepared with 4% limonene (ELI4) showed the highest percent of drug deposition in the skin (53%) and the highest local accumulation efficiency value (35.3). In vivo animal study showed that the lowest fungal burden produced with ELI4 chitosan gel. Clinical studies showed cure rate of 86% within 7 days treatment in case of limonene nanovesicular gel compared to 20% for market product (Lamisil® cream).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 88, 10 June 2016, Pages 91-100
نویسندگان
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